Phenoxypropylamines: a new series of squalene synthase inhibitors

J Med Chem. 1995 Oct 13;38(21):4157-60. doi: 10.1021/jm00021a003.

Authors

G R Brown¹, R J Butlin, S Chapman, M A Eakin, A J Foubister, S Freeman, D Griffiths, P J Harrison, M C Johnson, K B Mallion, et al.

Affiliation

¹ Cardiovascular and Metabolism Department, Zeneca Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, U.K.

PMID: 7473541
DOI: 10.1021/jm00021a003

No abstract available

MeSH terms

Administration, Oral
Animals
Anticholesteremic Agents / administration & dosage
Anticholesteremic Agents / chemistry*
Anticholesteremic Agents / pharmacology
Cholesterol / biosynthesis
Enzyme Inhibitors / administration & dosage
Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / pharmacology
Farnesyl-Diphosphate Farnesyltransferase / antagonists & inhibitors*
Mevalonic Acid / metabolism
Molecular Structure
Propylamines / administration & dosage
Propylamines / chemistry*
Propylamines / pharmacology
Rats
Structure-Activity Relationship

Substances

Anticholesteremic Agents
Enzyme Inhibitors
N-isopropyl-3-(4-acetylamino-2-allylphenoxy)propylamine
N-isopropyl-3-(4-amino-2-allylphenoxy)propylamine
N-isopropyl-3-(4-propionylamino-2-allylphenoxy)propylamine
Propylamines
Cholesterol
Farnesyl-Diphosphate Farnesyltransferase
Mevalonic Acid